Ghitm Gene Summary [Mouse]
Predicted to enable calcium channel activity and calcium:proton antiporter activity. Involved in inner mitochondrial membrane organization and mitochondrial potassium ion transmembrane transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ghitm |
| Official Name | growth hormone inducible transmembrane protein [Source:MGI Symbol;Acc:MGI:1913342] |
| Ensembl ID | ENSMUSG00000041028 |
| Bio databases IDs | |
| Aliases | growth hormone inducible transmembrane protein |
| Synonyms | 1010001P14Rik, BAE30441, Clone 42, DERP2, Growth hormone-inducible transmembrane, growth hormone inducible transmembrane protein, HSPC282, MICS1, My021, PTD010, TMBIM5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ghitm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- calcium:hydrogen antiporter
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- disorganization
- morphology
- disorganization in
- organization
- fragmentation in
- aggregation in
- aggregation
- transport in
- mitochondrial respiration in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ghitm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of release of cytochrome c from mitochondria
- apoptotic process
- calcium ion transport
- inner mitochondrial membrane organization
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium:hydrogen antiporter activity