Slc13a2 Gene Summary [Mouse]
Enables sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in 4-cell stage embryo; nervous system; and sensory organ. Orthologous to human SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc13a2 |
| Official Name | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 [Source:MGI Symbol;Acc:MGI:1276558] |
| Ensembl ID | ENSMUSG00000001095 |
| Bio databases IDs | |
| Aliases | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 |
| Synonyms | mNaDC-1, mucin, NaCT, NADC1, SDCT1, solute carrier family 13 member 2, solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc13a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:dicarboxylate symporter
- low affinity sodium:dicarboxylate symporter
- ArsB_NhaD_permease
- protein binding
- fumarate transporter
- alpha-ketoglutarate transporter
- succinate transporter
- transporter
- citrate transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ketoaciduria
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- accumulation in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc13a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- cellular response to lithium ion
- fumarate transport
- succinate transmembrane transport
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- sodium:dicarboxylate symporter activity
- low affinity sodium:dicarboxylate symporter activity
- succinate transmembrane transporter activity
- alpha-ketoglutarate transmembrane transporter activity
- fumarate transmembrane transporter activity