Rhebl1 Gene Summary [Mouse]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in TOR signaling; positive regulation of NF-kappaB transcription factor activity; and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; heart; and nervous system. Orthologous to human RHEBL1 (RHEB like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhebl1 |
| Official Name | Ras homolog enriched in brain like 1 [Source:MGI Symbol;Acc:MGI:1916409] |
| Ensembl ID | ENSMUSG00000023755 |
| Bio databases IDs | |
| Aliases | Ras homolog enriched in brain like 1 |
| Synonyms | 1810036J22RIK, Ras homolog enriched in brain like 1, Rheb2, RHEBL1c, RHEB like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhebl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhebl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- TOR signaling cascade
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- GDP binding