Foxp4 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxp4 |
| Official Name | forkhead box P4 [Source:MGI Symbol;Acc:MGI:1921373] |
| Ensembl ID | ENSMUSG00000023991 |
| Bio databases IDs | |
| Aliases | forkhead box P4 |
| Synonyms | 1200010K03Rik, 2310007G05Rik, AC113536.1, FKHLA, forkhead box P4, hFKHLA, LOC102555622, mFKHLA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- nucleic acid binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FOXP coiled-coil domain
- double-stranded DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- neoplasia
- prostate cancer
- metastasis
- prostatic carcinoma
- ischemic stroke
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- early-onset high myopia
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- oxygen consumption in
- migration
- invasion by
- differentiation
- colony formation
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity