Kmt2b Gene Summary [Mouse]
Enables histone H3K4 methyltransferase activity. Acts upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL1/2 complex. Is expressed in several structures, including alimentary system; inner cell mass; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 68; colorectal adenocarcinoma; dystonia 28, childhood-onset; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kmt2b |
| Official Name | lysine (K)-specific methyltransferase 2B [Source:MGI Symbol;Acc:MGI:109565] |
| Ensembl ID | ENSMUSG00000006307 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific methyltransferase 2B |
| Synonyms | 2610014H22Rik, CXXC10, DYT28, HRX2, lysine (K)-specific methyltransferase 2B, lysine methyltransferase 2B, mKIAA0304, MLL1B, MLL2, MLL4, MRD68, RGD1308331, TRX2, WBP-7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kmt2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- F/Y rich C-terminus
- Win motif
- protein binding
- Bromodomain
- unmethylated CpG binding
- histone lysine N-methyltransferase activity (H3-K4 specific)
- PHD-like zinc-binding domain
- zinc ion binding
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- PHD finger superfamily
- CXXC zinc finger domain
- F/Y-rich N-terminus
- PHD-zinc-finger like domain
Pathways
Biological processes and signaling networks where the Kmt2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- childhood-onset dystonia type 28
- cervical cancer
- hereditary disorder
- glioblastoma
- glioblastoma cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- metastasis
- colorectal carcinoma
- colorectal carcinomagenesis
role in cell
- accumulation in
- expression in
- binding in
- phosphorylation in
- migration
- apoptosis
- quantity
- invasion by
- sphere formation by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kmt2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone methyltransferase activity (H3-K4 specific)
- zinc ion binding
- protein binding
- unmethylated CpG binding