Pi16 Gene Summary [Mouse]
Predicted to enable peptidase inhibitor activity. Acts upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Located in extracellular space. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and neural retina. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pi16 |
| Official Name | peptidase inhibitor 16 [Source:MGI Symbol;Acc:MGI:1921366] |
| Ensembl ID | ENSMUSG00000024011 |
| Bio databases IDs | |
| Aliases | peptidase inhibitor 16 |
| Synonyms | 1200009H11RIK, CD364, Cripi, CRISP9, MSMBBP, peptidase inhibitor 16, PSPBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pi16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- neoplasia
- metastasis
- androgenic alopecia
- diverticular disease
- acute myeloid leukemia
- schizophrenia
role in cell
- growth
- phosphorylation in
- cellular infiltration by
- motility
- K63 polyubiquitination in
- Met1 linked ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pi16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth involved in cardiac muscle cell development
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- protein binding