Trpv2 Gene Summary [Mouse]
Enables calcium channel activity. Involved in positive regulation of axon extension; positive regulation of calcium ion import; and positive regulation of cold-induced thermogenesis. Located in cell body; cell surface; and growth cone. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and testis. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Trpv2 |
| Official Name | transient receptor potential cation channel, subfamily V, member 2 [Source:MGI Symbol;Acc:MGI:1341836] |
| Ensembl ID | ENSMUSG00000018507 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily V, member 2 |
| Synonyms | GRC, OTRPC2, transient receptor potential cation channel subfamily V member 2, transient receptor potential cation channel, subfamily V, member 2, VRL, VRL-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpv2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- calcium channel
- ion transporter
- Ankyrin repeats (3 copies)
- transient-receptor-potential calcium channel protein
- protein binding
- identical protein binding
- ion channel
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- cation channel
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- glioma
- glioma formation
- pruritus
- infection by bacteria
role in cell
- replication in
- expression in
- phosphorylation in
- cell viability
- apoptosis
- invasion
- proliferation
- migration
- depolarization
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- endomembrane system
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- Endoplasmic Reticulum
- growth cone
- cell membrane leading edge
- perikaryon
- axons
- axonal shafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpv2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to temperature stimulus
- calcium ion transmembrane transport
- positive regulation of axon extension
- sensory perception
- positive regulation of calcium ion import
Cellular Component
Where in the cell the gene product is active
- axonal growth cone
- melanosome
- cell body
- growth cone membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- protein binding
- calcium channel activity
- cation channel activity
- ion transmembrane transporter activity