Cmtr1 Gene Summary [Mouse]
Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmtr1 |
| Official Name | cap methyltransferase 1 [Source:MGI Symbol;Acc:MGI:1921407] |
| Ensembl ID | ENSMUSG00000024019 |
| Bio databases IDs | |
| Aliases | cap methyltransferase 1 |
| Synonyms | 1300018I05Rik, cap methyltransferase 1, FTSJD2, hMTr1, KIAA0082, LRRG00129, MTr1, RGD1307801 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmtr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA (nucleoside-2'-O-)-methyltransferase
- G-patch domain
- enzyme
- AdoMet_MTases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- prostate cancer
- colorectal cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- replication in
- colony formation
- complexity
- cellular infiltration by
- methylation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmtr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA capping
- mRNA processing
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- mRNA (nucleoside-2'-O-)-methyltransferase activity