Prepl Gene Summary [Mouse]
Enables peptidase activity. Involved in Golgi to plasma membrane protein transport and retrograde transport, endosome to Golgi. Located in Golgi apparatus and cytoskeleton. Colocalizes with trans-Golgi network. Is expressed in several structures, including diaphragm; nervous system; retina; tongue; and vertebral axis musculature. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prepl |
| Official Name | prolyl endopeptidase-like [Source:MGI Symbol;Acc:MGI:2441932] |
| Ensembl ID | ENSMUSG00000024127 |
| Bio databases IDs | |
| Aliases | prolyl endopeptidase-like |
| Synonyms | 2810457N15RIK, 9530014L06RIK, CMS22, D030028O16Rik, KIAA0436, mKIAA0436, prolyl endopeptidase-like, RGD1310143 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prepl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- peptidase
- Prolyl oligopeptidase, N-terminal beta-propeller domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- Golgi Apparatus
- Mitochondria
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prepl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- regulation of synaptic vesicle exocytosis
- Golgi to plasma membrane protein transport
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- cytoskeleton
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- peptidase activity