Bambi Gene Summary [Mouse]
Predicted to enable frizzled binding activity. Predicted to be involved in several processes, including positive regulation of epithelial to mesenchymal transition; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bambi |
| Official Name | BMP and activin membrane-bound inhibitor [Source:MGI Symbol;Acc:MGI:1915260] |
| Ensembl ID | ENSMUSG00000024232 |
| Bio databases IDs | |
| Aliases | BMP and activin membrane-bound inhibitor |
| Synonyms | 2610003H06Rik, BMP and activin membrane-bound inhibitor, NMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bambi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- punt binding
- frizzled binding
- BMP and activin membrane-bound inhibitor homolog C-terminus
- BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
- protein binding
- TFP
Pathways
Biological processes and signaling networks where the Bambi gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- insulin resistance
- androgenic alopecia
- weight gain
- metastasis
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- dementia
- senile lentigo
role in cell
- expression in
- proliferation
- survival
- differentiation
- migration
- activation in
- colony formation
- activation
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bambi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of BMP signaling pathway
- positive regulation of epithelial to mesenchymal transition
- positive regulation of protein binding
- positive regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- type II transforming growth factor beta receptor binding