BAMBI
BAMBI Gene Summary
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | BAMBI |
| Official Name | BMP and activin membrane bound inhibitor [Source:HGNC Symbol;Acc:HGNC:30251] |
| Ensembl ID | ENSG00000095739 |
| Bio databases IDs | |
| Aliases | BMP and activin membrane bound inhibitor |
| Synonyms | 2610003H06Rik,BMP and activin membrane-bound inhibitor,NMA |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- punt binding
- frizzled binding
- BMP and activin membrane-bound inhibitor homolog C-terminus
- BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
- protein binding
- TFP
Pathways
Biological processes and signaling networks where the BAMBI gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- HDAC1
- LMNA
- SMAD6
- miR-17-5p (and other miRNAs w/seed AAAGUGC)
- Zfp819
- CTNNB1
- SELENOF
- NFKB1
- TGFBR1
- BMPR1A
disease
- neoplasia
- prostate cancer
- insulin resistance
- androgenic alopecia
- weight gain
- metastasis
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
- dementia
- senile lentigo
regulated by
- lipopolysaccharide
- TGFB1
- NTRK1
- NFkB (complex)
- forskolin
- AHR
- FGF2
- TNF
- OSM
- ESR2
regulates
- IL10
- cholesterol
- CEBPB
- reactive oxygen species
- MMP14
- TGF beta
- OPRM1
- POMC
- WNT
- PENK
role in cell
- expression in
- proliferation
- survival
- differentiation
- migration
- activation in
- colony formation
- activation
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the BAMBI gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of BMP signaling pathway
- positive regulation of epithelial to mesenchymal transition
- positive regulation of protein binding
- positive regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of osteoblast differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- frizzled binding
- protein binding
- type II transforming growth factor beta receptor binding