Dync2li1 Gene Summary [Mouse]
Predicted to enable dynein heavy chain binding activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in apical part of cell; axoneme; and motile cilium. Is expressed in several structures, including gut; heart; lung; metanephros; and node. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dync2li1 |
| Official Name | dynein cytoplasmic 2 light intermediate chain 1 [Source:MGI Symbol;Acc:MGI:1913996] |
| Ensembl ID | ENSMUSG00000024253 |
| Bio databases IDs | |
| Aliases | dynein cytoplasmic 2 light intermediate chain 1 |
| Synonyms | 4933404O11Rik, CGI-60, D2LIC, dynein cytoplasmic 2 light intermediate chain 1, LIC3, mD2LIC, RGD1310286 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dync2li1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- dynein heavy chain binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Dync2li1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sitosterolemia
- short-rib thoracic dysplasia type 15 with polydactyly
- sitosterolemia type 1
- edema
- sitosterolemia type 2
- short-rib thoracic dysplasia type 1
- cholelithiasis
role in cell
- formation
- assembly
- lack
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary transition zone
- ciliary tip
- cilia
- apical compartment
- basal bodies
- centrosome
- Golgi Apparatus
- axonemes
- cytosol
- nuclear speckles
- cytoplasmic vesicles
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dync2li1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intraflagellar transport involved in cilium morphogenesis
- intraflagellar retrograde transport
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- Golgi apparatus
- axoneme
- microtubule
- cytoplasmic dynein complex
- motile cilium
- centrosome
- apical part of cell
- cytoplasm
- cilium
- cytosol
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding