Riok3 Gene Summary [Mouse]
Predicted to enable caspase binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to dsDNA; cellular response to virus; and negative regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in ganglia; sensory organ; trigeminal nerve; and vibrissa. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Riok3 |
| Official Name | RIO kinase 3 [Source:MGI Symbol;Acc:MGI:1914128] |
| Ensembl ID | ENSMUSG00000024404 |
| Bio databases IDs | |
| Aliases | RIO kinase 3 |
| Synonyms | 1200013N13Rik, D18Ertd331e, E130306C24RIK, Riok3 predicted, RIO kinase 3, SUDD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Riok3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protease binding
- RIO1 family
- protein binding
- Rio2, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- ocular hypertension
- lung cancer
- thoracic cancer
- lung metastasis
- advanced cancer
role in cell
- morphology
- invasion
- migration
- quantity
- segregation
- response by
- processing in
- degradation in
- association in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Riok3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MDA-5 signaling pathway
- positive regulation of innate immune response
- maturation of SSU-rRNA
- positive regulation of interferon-beta production
- innate immune response
- chromosome segregation
- defense response to virus
- negative regulation of protein complex assembly
- cellular response to dsRNA
- negative regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- preribosome, small subunit precursor
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity