RIOK3 Gene Summary [Human]
This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | RIOK3 |
| Official Name | RIO kinase 3 [Source:HGNC Symbol;Acc:HGNC:11451] |
| Ensembl ID | ENSG00000101782 |
| Bio databases IDs | |
| Aliases | RIO kinase 3 |
| Synonyms | 1200013N13Rik, D18Ertd331e, E130306C24RIK, Riok3 predicted, RIO kinase 3, SUDD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIOK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protease binding
- RIO1 family
- protein binding
- Rio2, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- ocular hypertension
- lung cancer
- thoracic cancer
- lung metastasis
- advanced cancer
role in cell
- morphology
- invasion
- migration
- quantity
- segregation
- response by
- processing in
- degradation in
- association in
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIOK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MDA-5 signaling pathway
- positive regulation of innate immune response
- maturation of SSU-rRNA
- positive regulation of interferon-beta production
- innate immune response
- chromosome segregation
- defense response to virus
- negative regulation of protein complex assembly
- cellular response to dsRNA
- negative regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- preribosome, small subunit precursor
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity