Fech Gene Summary [Rat]
Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fech |
| Official Name | ferrochelatase [Source:RGD Symbol;Acc:1307556] |
| Ensembl ID | ENSRNOG00000018053 |
| Bio databases IDs | |
| Aliases | ferrochelatase |
| Synonyms | EPP, EPP1, FCE, fch, Fcl, ferrochelatase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fech often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- Chelatase_Class_II
- ferrochelatase
- protein homodimerization
- iron-sulfur cluster domain
- iron ion binding
- enzyme
- iron-responsive element binding
- protein binding
- heme binding
- identical protein binding
- tetrapyrrole binding
Pathways
Biological processes and signaling networks where the Fech gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- erythropoietic protoporphyria type 1
- colorectal cancer
- erythropoietic protoporphyria
- myopathy with exercise intolerance Swedish type
- retinal neovascularization
role in cell
- proliferation
- differentiation
- survival
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fech gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- multicellular organismal iron ion homeostasis
- protoporphyrinogen IX metabolic process
- detection of UV
- cholesterol metabolic process
- heme biosynthetic process
- heme a biosynthetic process
- regulation of hemoglobin biosynthetic process
- response to xenobiotic stimulus
- response to light stimulus
- heme b biosynthetic process
- heme O biosynthetic process
- response to ethanol
- erythrocyte differentiation
- response to methylmercury
- response to insecticide
- regulation of eIF2 alpha phosphorylation by heme
- response to platinum ion
- response to arsenic-containing substance
- very-low-density lipoprotein particle assembly
- cellular response to dexamethasone stimulus
- response to lead ion
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ferrochelatase activity
- identical protein binding
- protein homodimerization activity
- protein binding
- ferrous iron binding
- iron-responsive element binding
- 2 iron, 2 sulfur cluster binding
- heme binding