Myo1e Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; actin filament binding activity; and calmodulin binding activity. Involved in glomerular basement membrane development; glomerular filtration; and podocyte development. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in adherens junction; brush border; and cytoplasm. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Myo1e |
| Official Name | myosin IE [Source:MGI Symbol;Acc:MGI:106621] |
| Ensembl ID | ENSMUSG00000032220 |
| Bio databases IDs | |
| Aliases | myosin IE |
| Synonyms | 2310020N23Rik, 9130023P14Rik, AA407778, FSGS6, HuncM-IC, LOC100504972, MYO1C, myosin-1e, Myosin heavy chain 1b, Myosin-IE, Myr3, MYR5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo1e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin and Kinesin motor domain
- calmodulin binding
- enzyme
- protein binding
- ATPase
- phosphatidylinositol binding
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
- actin filament binding
- binding protein
- Unconventional myosin tail, actin- and lipid-binding
- Myosin
- cargo binding domain
Pathways
Biological processes and signaling networks where the Myo1e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- metabolic syndrome X
- nephrosis
- coronary artery disease
- focal segmental glomerulosclerosis type 6
- hematuria
- albuminuria
- Dupuytren contracture
- Alzheimer disease
- glomerulosclerosis
role in cell
- activation in
- cell spreading
- formation
- formation in
- loss
- development
- adhesion
- effacement
- cell rolling
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cytosol
- cuticular plate
- endocytotic vesicle
- brush border
- pseudopodia
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo1e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glomerular basement membrane development
- post-embryonic hemopoiesis
- glomerulus development
- glomerular visceral epithelial cell development
- in utero embryonic development
- glomerular filtration
- platelet-derived growth factor receptor signaling pathway
- actin filament organization
- vasculogenesis
- endocytosis
Cellular Component
Where in the cell the gene product is active
- myosin complex
- adherens junction
- extracellular vesicular exosome
- cytoskeleton
- brush border
- microvillus
- cytoplasm
- actin cytoskeleton
- clathrin-coated endocytic vesicle
- cuticular plate
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATPase activity
- ATP binding
- calmodulin binding
- protein binding
- phosphatidylinositol binding
- microfilament motor activity