Socs7 Gene Summary [Mouse]
Enables phosphorylation-dependent protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; eye; liver; lung; and testis. Orthologous to human SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Socs7 |
| Official Name | suppressor of cytokine signaling 7 [Source:MGI Symbol;Acc:MGI:2651588] |
| Ensembl ID | ENSMUSG00000038485 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 7 |
| Synonyms | 2310063P06Rik, NAP4, NCKAP4, Suppressor of cytokine signaling 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Socs7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- protein binding activity, bridging
- SOCS
- Src homology 2 (SH2) domain
- protein binding
Pathways
Biological processes and signaling networks where the Socs7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- hypoglycemia
- growth failure
- hydrocephalus
- macrocephaly
- bleeding
- serous ovarian cancer
- high-grade serous ovarian carcinoma
- high-grade serous epithelial ovarian or fallopian tube or primary peritoneal cancer
role in cell
- proliferation
- cell viability
- expression in
- differentiation
- cell cycle progression
- migration
- ubiquitination in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Socs7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- phosphatidylinositol phosphorylation
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- phosphatidylinositol 3-kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- 1-phosphatidylinositol-3-kinase regulator activity