Trpm6 Gene Summary [Mouse]
Enables monoatomic cation channel activity and protein kinase activity. Acts upstream of or within metal ion transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including cochlea; colon; extraembryonic component; ganglia; and genitourinary system. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpm6 |
| Official Name | transient receptor potential cation channel, subfamily M, member 6 [Source:MGI Symbol;Acc:MGI:2675603] |
| Ensembl ID | ENSMUSG00000024727 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily M, member 6 |
| Synonyms | CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6, transient receptor potential cation channel, subfamily M, member 6, TRPM6/CHAK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpm6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha kinase family
- protein serine/threonine kinase
- protein kinase
- Ion transport protein
- calcium ion transporter
- tetramerization domain of TRPM
- ATP-binding domain
- calcium channel
- Alpha-kinase family
- protein binding
- kinase
- kinase domain
- SLOG in TRPM
- magnesium ion transporter
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypomagnesemia with secondary hypocalcemia
- gestational diabetes mellitus
- hereditary disorder
- acute myeloid leukemia
- kidney stones
- schizophrenia
- spina bifida occulta
- exencephaly
- diabetic nephropathy
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membranes
- cellular membrane
- Nucleus
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpm6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein tetramerization
- calcium ion transmembrane transport
- metal ion transport
- response to toxin
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- calcium channel activity
- cation channel activity
- protein serine/threonine kinase activity