Myh14 Gene Summary [Mouse]
Enables several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh14 |
| Official Name | myosin, heavy polypeptide 14 [Source:MGI Symbol;Acc:MGI:1919210] |
| Ensembl ID | ENSMUSG00000030739 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 14 |
| Synonyms | 2400004E04RIK, DFNA4, DFNA4A, FP17425, II-C, Kv3, MHC16, MHC IIC, MYH17, myosin, myosin heavy chain 14, myosin, heavy polypeptide 14, Myosin IIC, NHMCII, NMHC II, NMHC-II-C, PNMHH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- ATP binding
- microfilament motor protein
- helix-rich Mycoplasma protein
- enzyme
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- tail domain
- Centrosomal protein of 63 kDa
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- PspA/IM30 family
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- Myosin tail
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- actin filament binding
- RecF/RecN/SMC N terminal domain
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Myosin
Pathways
Biological processes and signaling networks where the Myh14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cardiac hypertrophy
- autosomal dominant 4 deafness
- Kawasaki disease
- sporadic age-related sensorineural hearing loss
- degeneration of lumbar intervertebral disc
- hypertrophic cardiomyopathy
- peripheral neuropathy, myopathy, hoarseness, and hearing loss
- androgenic alopecia
- hypoplasia
role in cell
- proliferation
- formation
- organization
- translocation
- binding in
- movement
- abnormal morphology
- formation in
- function
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- Cytoplasm
- apical compartment
- actin cytoskeleton
- Nucleus
- contractile rings
- actin filaments
- Flemming body
- cytosol
- growth cone
- neurites
- myosin filaments
- actin stress fibers
- brush border
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- sensory perception of sound
- skeletal muscle contraction
- actomyosin structure organization
- skeletal muscle tissue development
- actin filament-based movement
- mitochondrion organization
- vocalization behavior
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular vesicular exosome
- brush border
- cytoplasm
- myosin II complex
- membrane
- stress fiber
- myosin filament
- cytosol
- actomyosin
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- microfilament motor activity