Ovol1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ovol1 |
| Official Name | ovo like zinc finger 1 [Source:MGI Symbol;Acc:MGI:1330290] |
| Ensembl ID | ENSMUSG00000024922 |
| Bio databases IDs | |
| Aliases | ovo like zinc finger 1 |
| Synonyms | HOVO1, movo1, Ovo1, ovo like transcriptional repressor 1, ovo like zinc finger 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ovol1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- gout
- asthma
- osteoarthritis
- atopic dermatitis
- breast carcinoma
- kidney stones
- skin barrier defect
- IgA nephropathy
- eczema
role in cell
- proliferation
- expression in
- number
- development
- cellular reprogramming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ovol1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte proliferation
- spermatogenesis
- germline cell cycle switching, mitotic to meiotic cell cycle
- mesoderm development
- skin development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of keratinocyte proliferation
- negative regulation of transcription from RNA polymerase II promoter
- epidermal cell differentiation
- negative regulation of stem cell proliferation
- kidney development
- stem cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity