Slc1a1 Gene Summary [Mouse]
Enables amino acid transmembrane transporter activity; identical protein binding activity; and monoatomic anion channel activity. Involved in several processes, including cell surface receptor signaling pathway; learning or memory; and nervous system development. Acts upstream of or within several processes, including behavioral fear response; cellular response to bisphenol A; and cellular response to mercury ion. Located in endosome membrane; membrane raft; and plasma membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; apical plasma membrane; and recycling endosome. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Slc1a1 |
| Official Name | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [Source:MGI Symbol;Acc:MGI:105083] |
| Ensembl ID | ENSMUSG00000024935 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| Synonyms | D130048G10RIK, DCBXA, EAAC-1, EAAC2, EAAT3, EXCITATORY AMINO ACID TRANSPORTER 3, GLUTAMATE TRANSPORTER, Glutamate transporter 1, hEAAC1, MEAAC1, REAAC1, SCZD18, solute carrier family 1 member 1, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- D-amino acid transporter
- sulfur amino acid transporter
- glutamate:sodium symporter
- dicarboxylic acid transporter
- glutamate binding
- high-affinity glutamate transporter
- protein binding
- chloride transporter
- identical protein binding
- neutral amino acid transporter
- organic cation transporter
- anion channel
- glutamate transporter
- aspartate transporter
- C4-dicarboxylate transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc1a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allodynia
- liver cancer
- epithelial cancer
- schizophrenia
- cervical spondylotic myelopathy
- amyotrophic lateral sclerosis
- hepatitis B virus-related hepatocellular carcinoma
- non-small cell lung carcinoma
- non-small cell lung cancer
- major depression
role in cell
- expression in
- cell death
- apoptosis
- growth
- organization
- degeneration
- response by
- number
- clearance by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- apical membrane
- synaptic membrane
- endosomal membrane
- dendritic spines
- neurites
- dendrite initial segments
- synaptosomes
- synapse
- glial cell projections
- recycling endosomes
- synaptic-like microvesicles
- membrane rafts
- detergent insoluble microdomains
- membrane processes
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic shafts
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- dopamine metabolic process
- heart contraction
- cellular zinc ion homeostasis
- dopamine receptor signaling pathway
- blood vessel morphogenesis
- neurogenesis
- response to axon injury
- memory
- glutamate receptor signaling pathway
- neurotransmitter transport
- motor neuron apoptotic process
- response to anesthetic
- long-term synaptic potentiation
- zinc ion transmembrane transport
- maintenance of blood-brain barrier
- synapse organization
- L-glutamate import
- synaptic transmission
- response to morphine
- brain development
- superoxide metabolic process
- cellular response to mercury ion
- cellular response to ammonium ion
- gene expression
- transepithelial transport
- cellular response to organic cyclic compound
- adult behavior
- regulation of protein targeting to membrane
- response to xenobiotic stimulus
- negative regulation of neuron apoptotic process
- grooming behavior
- ion transport
- locomotory behavior
- cytokine-mediated signaling pathway
- cellular response to cocaine
- righting reflex
- glutathione biosynthetic process
- cysteine transport
- behavioral fear response
- response to amphetamine
- regulation of protein phosphorylation
- retina layer formation
- cellular response to oxidative stress
- L-glutamate transport
- D-aspartate import
- D-aspartate transport
- L-aspartate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- neuronal cell body
- perikaryon
- axon terminus
- plasma membrane
- cell surface
- early endosome membrane
- dendrite
- late endosome membrane
- synaptic cleft
- extracellular vesicular exosome
- dendritic shaft
- membrane
- membrane raft
- dendritic spine
- asymmetric synapse
- recycling endosome membrane
- axon
- apical plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- anion channel activity
- L-aspartate transmembrane transporter activity
- glutamate binding
- chloride transmembrane transporter activity
- cysteine transmembrane transporter activity
- high-affinity glutamate transmembrane transporter activity
- glutamate:sodium symporter activity
- L-glutamate transmembrane transporter activity