Arl6ip5 Gene Summary [Mouse]
Predicted to enable transmembrane transporter binding activity. Involved in negative regulation of L-glutamate import across plasma membrane. Acts upstream of or within with a negative effect on L-glutamate import across plasma membrane and protein localization to plasma membrane. Acts upstream of or within several processes, including L-glutamate transmembrane transport; cellular response to oxidative stress; and glutathione metabolic process. Is active in plasma membrane and presynaptic cytosol. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ARL6IP5 (ARF like GTPase 6 interacting protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl6ip5 |
| Official Name | ADP-ribosylation factor-like 6 interacting protein 5 [Source:MGI Symbol;Acc:MGI:1929501] |
| Ensembl ID | ENSMUSG00000035199 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 6 interacting protein 5 |
| Synonyms | 5930404D22Rik, addicsin, addiscin, ADP-ribosylation factor-like 6 interacting protein 5, Adp ribosylation like factor 6 interacting protein 5, Aip-5, ARF like GTPase 6 interacting protein 5, DERP11, GTRAP3-18, hp22, HSPC127, jmx, JWA, PRA2, PRAF3, Yip6b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl6ip5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRA1 family protein
- ion channel binding
- protein binding
Pathways
Biological processes and signaling networks where the Arl6ip5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- mucopolysaccharidosis type IVB
- survival
- lung adenocarcinoma
- lung adenocarcinoma formation
- kyphosis
- osteoporosis
- melanoma
- melanoma cancer
role in cell
- growth
- expression in
- apoptosis
- function
- response by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl6ip5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- negative regulation of transport
- induction of apoptosis by oxidative stress
- learning or memory
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of L-glutamate transport
- negative regulation of mitochondrial membrane potential
- glutathione metabolic process
- positive regulation of apoptotic process
- cellular response to oxidative stress
- L-glutamate transport
- cellular response to organic cyclic compound
- positive regulation of stress-activated MAPK cascade
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoskeleton
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding