Dntt Gene Summary [Mouse]
Enables DNA nucleotidylexotransferase activity. Acts upstream of or within DNA metabolic process. Predicted to be located in cytosol; euchromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in bone marrow; ovary; submandibular gland; testis; and thymus. Orthologous to human DNTT (DNA nucleotidylexotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dntt |
| Official Name | deoxynucleotidyltransferase, terminal [Source:MGI Symbol;Acc:MGI:98659] |
| Ensembl ID | ENSMUSG00000025014 |
| Bio databases IDs | |
| Aliases | deoxynucleotidyltransferase, terminal |
| Synonyms | deoxynucleotidyltransferase, terminal, DNA nucleotidylexotransferase, TDT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dntt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- BRCT
- DNA polymerase beta thumb
- DNA binding domain
- catalytic domain
- DNA polymerase X family
- enzyme
- protein binding
- DNA nucleotidylexotransferase
- nucleotide-binding domain
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Fingers domain of DNA polymerase lambda
- BRCA1 C Terminus (BRCT) domain
- DNA polymerase beta palm
- breast cancer carboxy-terminal domain
Pathways
Biological processes and signaling networks where the Dntt gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T-cell lymphoblastic lymphoma
- T-cell non-Hodgkin disease
- liver cancer
- T acute lymphoblastic leukemia
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- early pre-B-cell acute lymphoblastic leukemia
- Burkitt lymphoma
- splenic cancer
regulates
- deoxynucleotides mixture
- polynucleotides
- nucleotide
- TCR (complex)
role in cell
- differentiation
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dntt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ATP
- DNA biosynthetic process
- DNA metabolic process
- double-strand break repair via nonhomologous end joining
- DNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytosol
- nuclear matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- metal ion binding
- DNA nucleotidylexotransferase activity