Efhc2 Gene Summary [Mouse]
Involved in flagellated sperm motility. Acts upstream of or within cellular response to leukemia inhibitory factor. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human EFHC2 (EF-hand domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efhc2 |
| Official Name | EF-hand domain (C-terminal) containing 2 [Source:MGI Symbol;Acc:MGI:1921655] |
| Ensembl ID | ENSMUSG00000025038 |
| Bio databases IDs | |
| Aliases | EF-hand domain (C-terminal) containing 2 |
| Synonyms | 4933407D04Rik, dJ1158H2.1, EF-hand domain containing 2, EF-hand domain (C-terminal) containing 2, mRib72-2, MRX74, RGD1563388 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efhc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DM10 domain
- protein binding
- Domains in hypothetical proteins in Drosophila, C
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efhc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- axonemal microtubule
- cilium basal body
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding