Maea Gene Summary [Mouse]
Enables actin binding activity. Acts upstream of or within cytoskeleton organization and enucleate erythrocyte development. Located in actin cytoskeleton. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maea |
| Official Name | macrophage erythroblast attacher [Source:MGI Symbol;Acc:MGI:1891748] |
| Ensembl ID | ENSMUSG00000079562 |
| Bio databases IDs | |
| Aliases | macrophage erythroblast attacher |
| Synonyms | 1110030D19Rik, EMLP, EMP, GID9, HLC-10, LOC101928676, macrophage erythroblast attacher, macrophage erythroblast attacher, E3 ubiquitin ligase, P44EMLP, PIG5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maea often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- CT11-RanBPM
- actin binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- C-terminal to LisH motif
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- spindle apparatus
- cytoskeleton
- Cytoplasm
- cellular membrane
- actin cytoskeleton
- Nucleus
- contractile rings
- cytosol
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maea gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- proteasomal ubiquitin-dependent protein catabolic process
- cytoskeleton organization
- negative regulation of myeloid cell apoptotic process
- enucleate erythrocyte development
- cell adhesion
- regulation of mitotic cell cycle
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- ubiquitin ligase complex
- actomyosin contractile ring
- cytoplasm
- spindle
- nuclear matrix
- plasma membrane
- GID complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- actin binding
- metal ion binding