Exoc8 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Predicted to be located in cell leading edge and late endosome. Predicted to be part of exocyst. Is expressed in several structures, including adrenal gland; genitourinary system; lung; nervous system; and pancreas. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc8 |
| Official Name | exocyst complex component 8 [Source:MGI Symbol;Acc:MGI:2142527] |
| Ensembl ID | ENSMUSG00000074030 |
| Bio databases IDs | |
| Aliases | exocyst complex component 8 |
| Synonyms | EXO84, Exo84p, exocyst complex component 8, LOC149371, NEDMISB, SEC84 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exoc8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exocyst component 84 C-terminal
- PH domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- Vps51/Vps67
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Exoc8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, seizures, and brain atrophy
role in cell
- expression in
- growth
- number
- disassembly
- organization
- exocytosis by
- degradation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- endosomes
- cytosol
- late endosomes
- multivesicular bodies
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exoc8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- endosome organization
- cytokinesis after mitosis
- extracellular matrix disassembly
- protein transport
- vesicle docking involved in exocytosis
- Golgi to plasma membrane transport
- regulation of macroautophagy
- protein localization
- exocytosis
Cellular Component
Where in the cell the gene product is active
- growth cone
- perinuclear region of cytoplasm
- cell leading edge
- membrane
- late endosome
- cytosol
- plasma membrane
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol binding
- small GTPase binding