Rab3a Gene Summary [Mouse]
Enables GTP-dependent protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including modulation of chemical synaptic transmission; secretion by cell; and synaptic vesicle clustering. Acts upstream of or within several processes, including chemical synaptic transmission; maintenance of presynaptic active zone structure; and synaptic vesicle maturation. Located in several cellular components, including cytoplasmic vesicle; presynaptic active zone; and terminal bouton. Is active in synaptic vesicle membrane. Is expressed in brain and inner ear. Orthologous to human RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab3a |
| Official Name | RAB3A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:97843] |
| Ensembl ID | ENSMUSG00000031840 |
| Bio databases IDs | |
| Aliases | RAB3A, member RAS oncogene family |
| Synonyms | RAB3, RAB3A, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- Ras family
- protein binding activity, bridging
- enzyme
- effector domain
- CXC prenylation site
- myosin binding
- Rabphilin3 binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- GTP binding domain
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- alpha helix
- GTPase
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- ATPase binding
- ADP-ribosylation factor family
- CAAX box
- small GTP-binding protein domain
- GTPase domain
- Rab subfamily of small GTPases
Pathways
Biological processes and signaling networks where the Rab3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- cutaneous melanoma
- cutaneous melanoma cancer
- colon cancer
- dyspnea
- hyperglycemia
- Huntington disease
- cyanosis
- infection by Human enterovirus 71
- infection by Dengue virus 2
role in cell
- formation
- apoptosis
- number
- binding in
- transport
- exocytosis
- maturation
- development
- trafficking
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic synaptosomal fraction
- synaptic plasma membrane fractions
- membrane fraction
- intracellular nanovesicle
- synaptic vesicle membrane
- cytoplasmic vesicle membrane
- presynaptic regions
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- secretory granule membrane
- cytosol
- vesicle membrane
- acrosome
- insulin secretory granules
- synaptic vesicles
- growth cone
- neurites
- synaptosomes
- synapse
- transport vesicles
- dense-core vesicles
- secretory vesicles
- endocytotic vesicle
- secretory granules
- axons
- axon terminals
- clathrin-coated vesicles
- detergent-soluble fraction
- synaptic vesicle fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular synaptic transmission
- insulin secretion
- post-embryonic development
- synaptic vesicle clustering
- exocytosis
- positive regulation of exocytosis
- synaptic vesicle transport
- axonogenesis
- constitutive secretory pathway
- regulated secretory pathway
- regulation of synaptic vesicle fusion to presynaptic membrane
- synaptic vesicle exocytosis
- response to electrical stimulus
- sensory perception of touch
- lung development
- acrosomal vesicle exocytosis
- protein secretion
- mitochondrion organization
- respiratory system process
- lysosome localization
- maintenance of presynaptic active zone structure
- plasma membrane repair
- calcium ion-dependent exocytosis
- synaptic vesicle maturation
- regulation of short-term neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- clathrin sculpted acetylcholine transport vesicle membrane
- clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
- synaptic vesicle
- clathrin sculpted glutamate transport vesicle membrane
- plasma membrane
- lysosome
- secretory granule membrane
- clathrin sculpted monoamine transport vesicle membrane
- endosome
- perinuclear region of cytoplasm
- presynaptic active zone
- terminal button
- acrosomal vesicle
- cytosol
- synaptic vesicle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- protein binding, bridging
- GTP-dependent protein binding
- myosin V binding