Sema4g Gene Summary [Mouse]
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; liver; nervous system; sensory organ; and urinary system. Orthologous to human SEMA4G (semaphorin 4G). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema4g |
| Official Name | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [Source:MGI Symbol;Acc:MGI:1347047] |
| Ensembl ID | ENSMUSG00000025207 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G |
| Synonyms | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G, semaphorin 4G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema4g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema4g gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema4g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding