Dscaml1 Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Involved in dendrite self-avoidance and negative regulation of cell adhesion. Predicted to be located in cell surface. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including genitourinary system; liver; nervous system; nose; and spleen. Orthologous to human DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dscaml1 |
| Official Name | DS cell adhesion molecule like 1 [Source:MGI Symbol;Acc:MGI:2150309] |
| Ensembl ID | ENSMUSG00000032087 |
| Bio databases IDs | |
| Aliases | DS cell adhesion molecule like 1 |
| Synonyms | 4921507G06Rik, 4930435C18RIK, DSCAM2, DS cell adhesion molecule-like 1, mKIAA1132 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dscaml1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- FN3
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- intracellular domain
- Immunoglobulin I-set domain
- protein homodimerization
- Fibronectin type 3 domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- refractive error
- insomnia
- myopia
- essential tremor
- dementia
- hyperopia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- expression in
- outgrowth
- adhesion
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dscaml1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- axonogenesis
- dendrite self-avoidance
- axon guidance
- homophilic cell adhesion
- brain development
- cell fate determination
- embryonic skeletal system morphogenesis
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- synapse
- axon
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity