Plxnb2 Gene Summary [Mouse]
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Plxnb2 |
| Official Name | plexin B2 [Source:MGI Symbol;Acc:MGI:2154239] |
| Ensembl ID | ENSMUSG00000036606 |
| Bio databases IDs | |
| Aliases | plexin B2 |
| Synonyms | AI841137, Debt, dJ402G11.3, lncFAL, MM1, Nbla00445, NM-4, PLEXB2, Plexin B2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxnb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- cytoplasmic domain
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- PDZ binding motif
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Plxnb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- hypertension
- colorectal cancer
- biliary tract cancer
- cutaneous melanoma
- epithelial cancer
- epithelial neoplasia
- cancer
- COVID-19
- skin cancer
phenotypes
- abnormal response to tactile stimuli
- abnormal urination
- decreased circulating triglyceride level
- abnormal brain morphology
- abnormal brain ventricle morphology
- abnormal cerebellar Purkinje cell layer
- abnormal cerebellar cortex morphology
- abnormal cerebellar foliation
- abnormal cerebellar granule cell migration
- abnormal cerebellar granule cell morphology
- abnormal cerebellar granule layer morphology
- abnormal cerebellum external granule cell layer morphology
- abnormal cerebellum morphology
- abnormal choroid plexus morphology
- abnormal coat/hair pigmentation
- abnormal diencephalon morphology
- abnormal neural tube morphology
- abnormal neuronal precursor cell migration
- abnormal olfactory bulb development
- abnormal olfactory bulb granule cell morphology
- abnormal olfactory bulb internal plexiform layer morphology
- abnormal olfactory bulb interneuron morphology
- abnormal olfactory bulb layer morphology
- abnormal olfactory bulb mitral cell layer morphology
- abnormal olfactory bulb periglomerular cell morphology
- abnormal radial glial cell morphology
- abnormal rostral migratory stream morphology
- abnormal striatum morphology
- abnormal ureteric bud tip morphology
- absent cerebellar foliation
- belly spot
- curly tail
- decreased neuronal precursor proliferation
- double kidney pelvis
- double ureter
- duplex kidney
- ectopic Purkinje cell
- ectopic cerebellar granule cells
- enlarged brain ventricles
- exencephaly
- impaired branching involved in ureteric bud morphogenesis
- incomplete caudal neuropore closure
- incomplete rostral neuropore closure
- increased body weight
- neonatal lethality incomplete penetrance
- open neural tube
- prenatal lethality complete penetrance
- renal hypoplasia
- small cerebellum
- small kidney
- spina bifida
role in cell
- expression in
- proliferation
- apoptosis
- activation
- migration
- assembly
- formation
- abnormal morphology
- adhesion
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- Extracellular Space
- cellular membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxnb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of translation
- negative regulation of cell adhesion
- brain development
- homophilic cell adhesion
- neuroblast proliferation
- positive regulation of axonogenesis
- neural tube closure
- regulation of protein phosphorylation
- regulation of GTPase activity
- positive regulation of neuron projection development
- regulation of cell migration
- regulation of neuron migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- extracellular vesicular exosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- semaphorin receptor activity