Shisa5 Gene Summary [Mouse]
Predicted to enable WW domain binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in endoplasmic reticulum and nuclear envelope. Is expressed in blood vessel; cortical plate; extraembryonic component; foregut diverticulum; and meninges. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shisa5 |
| Official Name | shisa family member 5 [Source:MGI Symbol;Acc:MGI:1915044] |
| Ensembl ID | ENSMUSG00000025647 |
| Bio databases IDs | |
| Aliases | shisa family member 5 |
| Synonyms | 2310008D10Rik, 6430628I05Rik, mShisa5, SCOTIN, shisa family member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shisa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt and FGF inhibitory regulator
- WW domain binding
- protein binding
- Cancer Associated Small Integral Membrane Open reading frame 1 (CASIMO1)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear membrane fraction
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum lumen
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shisa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nuclear membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding