Clcf1 Gene Summary [Mouse]
Enables cytokine activity. Involved in cell surface receptor signaling pathway via STAT; positive regulation of B cell activation; and positive regulation of astrocyte differentiation. Acts upstream of or within B cell differentiation and cell surface receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular space. Predicted to be part of CNTFR-CLCF1 complex and CRLF-CLCF1 complex. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and skeletal musculature. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 2. Orthologous to human CLCF1 (cardiotrophin like cytokine factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcf1 |
| Official Name | cardiotrophin-like cytokine factor 1 [Source:MGI Symbol;Acc:MGI:1930088] |
| Ensembl ID | ENSMUSG00000040663 |
| Bio databases IDs | |
| Aliases | cardiotrophin-like cytokine factor 1 |
| Synonyms | BSF-3, cardiotrophin-like cytokine factor 1, CISS2, CLC, NNT-1, NNT-1/BSF-3, NR6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clcf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ciliary neurotrophic factor receptor binding
- protein binding
- receptor binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Clcf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cold-induced sweating syndrome 2
- insulin resistance
- chronic periodontal disease
- obesity
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- hypothermia
- hyperplasia
role in cell
- expression in
- apoptosis
- differentiation
- proliferation
- survival
- production in
- accumulation in
- phosphorylation in
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clcf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of isotype switching to IgE isotypes
- B cell differentiation
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of immunoglobulin production
- positive regulation of B cell proliferation
- positive regulation of astrocyte differentiation
- cell surface receptor signaling pathway
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of neuron apoptotic process
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- CRLF-CLCF1 complex
- CNTFR-CLCF1 complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- receptor binding
- ciliary neurotrophic factor receptor binding