Pigq Gene Summary [Mouse]
Contributes to phosphatidylinositol N-acetylglucosaminyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 4. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pigq |
| Official Name | phosphatidylinositol glycan anchor biosynthesis, class Q [Source:MGI Symbol;Acc:MGI:1333114] |
| Ensembl ID | ENSMUSG00000025728 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis, class Q |
| Synonyms | c407A10.1, DEE77, EIEE77, GPI1, Gpi1h, Gpi1p, GPIBD19, Gpih, MCAHS4, phosphatidylinositol glycan anchor biosynthesis class Q, phosphatidylinositol glycan anchor biosynthesis, class Q |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pigq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol N-acetylglucosaminyltransferase
- N-acetylglucosaminyl transferase component (Gpi1)
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epilepsy
- early infantile epileptic encephalopathy type 77
- hereditary disorder
- insomnia
- degeneration of lumbar intervertebral disc
role in cell
- phagocytosis by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pigq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- GPI anchor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding