Cplx2 Gene Summary [Mouse]
Predicted to enable calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in positive regulation of synaptic plasticity and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Is active in calyx of Held and glutamatergic synapse. Is expressed in nervous system; retina layer; and skeletal muscle. Used to study schizophrenia. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cplx2 |
| Official Name | complexin 2 [Source:MGI Symbol;Acc:MGI:104726] |
| Ensembl ID | ENSMUSG00000025867 |
| Bio databases IDs | |
| Aliases | complexin 2 |
| Synonyms | 921-L, AC164441.1, AI413745, AW492120, Complexin2, CPX-2, CX II, DKFZP547D155, Gm2826, Gm34843, Hfb1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cplx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- calcium-dependent protein binding
- Synaphin protein
- syntaxin-1 binding
- Complexin_NTD
- protein binding
Pathways
Biological processes and signaling networks where the Cplx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gait disturbance
- non-insulin-dependent diabetes mellitus
- schizophrenia
- pervasive developmental disorder
- insomnia
- COVID-19
- Huntington disease
- Parkinson disease
- motor dysfunction or movement disorder
- attention deficit hyperactivity disorder
role in cell
- expression in
- long-term potentiation
- plasticity
- priming
- exocytosis
- exocytosis by
- docking
- transmission
- miniature excitatory postsynaptic currents in
- calcium triggered exocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- cell surface
- postsynaptic region
- synaptic vesicles
- synapse
- membrane processes
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cplx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- vesicle docking involved in exocytosis
- positive regulation of synaptic plasticity
- cell differentiation
- nervous system development
- regulation of synaptic vesicle fusion to presynaptic membrane
- synaptic vesicle exocytosis
- regulation of exocytosis
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- terminal button
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
- cytosol
- SNARE complex
- synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
- perikaryon
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin-1 binding
- calcium-dependent protein binding
- SNARE binding