Cplx3 Gene Summary [Mouse]
Enables SNARE binding activity and neurotransmitter transmembrane transporter activity. Involved in insulin secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in cytosol; plasma membrane; and synapse. Is active in photoreceptor ribbon synapse; presynaptic active zone membrane; and synaptic vesicle membrane. Is expressed in brain; cerebral cortex; and cortical layer V. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cplx3 |
| Official Name | complexin 3 [Source:MGI Symbol;Acc:MGI:2384571] |
| Ensembl ID | ENSMUSG00000039714 |
| Bio databases IDs | |
| Aliases | complexin 3 |
| Synonyms | complexin 3, CPX-III, ERGIC-53L, ERGL, Lamn1l, Lman1l, Nbla11589, RGD1560104 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cplx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Synaphin protein
- Complexin_NTD
- neurotransmitter transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- cytosol
- presynaptic membrane
- synapse
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cplx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- insulin secretion
- regulation of synaptic vesicle fusion to presynaptic membrane
- synaptic vesicle exocytosis
- visual perception
Cellular Component
Where in the cell the gene product is active
- terminal button
- SNARE complex
- cytosol
- synaptic vesicle membrane
- presynaptic active zone membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- syntaxin binding
- SNARE binding