Trak2 Gene Summary [Mouse]
Predicted to enable several functions, including GABA receptor binding activity; TPR domain binding activity; and cytoskeletal protein binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; negative regulation of axonogenesis; and organelle transport along microtubule. Predicted to be located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including brain; genitourinary system; liver; retina nuclear layer; and spleen. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trak2 |
| Official Name | trafficking protein, kinesin binding 2 [Source:MGI Symbol;Acc:MGI:1918077] |
| Ensembl ID | ENSMUSG00000026028 |
| Bio databases IDs | |
| Aliases | trafficking protein, kinesin binding 2 |
| Synonyms | 2900022D04RIK, 4733401O11Rik, ALS2CR3, CALS-C, GRIF-1, KIAA0549, MILT2, mKIAA0549, OIP98, trafficking kinesin protein 2, trafficking protein, kinesin binding 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trak2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAP1 N-terminal conserved region
- kinesin1 binding domain
- hrs-binding domain
- Kinesin associated protein
- enzyme binding
- protein domain specific binding
- protein binding
- receptor binding
- Miro1-binding domain
- kinesin binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast carcinoma
- psoriasis
- non-melanoma skin cancer
- systemic juvenile idiopathic arthritis
- cocaine-related disorder
- Huntington disease
role in cell
- expression in
- growth
- degradation in
- depletion in
- morphogenesis
- axonogenesis
- branching
- branching in
- efflux in
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- Cytoplasm
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- plasma membrane projections
- early endosomes
- perikaryon
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trak2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- mitochondrion distribution
- vesicle transport along microtubule
- neurogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- early endosome
- cytoplasm
- mitochondrion
- dendrite cytoplasm
- cytoplasmic vesicle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- myosin binding
- GABA receptor binding
- receptor binding