Snapin Gene Summary [Mouse]
Predicted to enable SNARE binding activity. Involved in anterograde synaptic vesicle transport; negative regulation of neuron projection development; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in acrosomal vesicle; cytosol; and manchette. Part of BLOC-1 complex. Is active in microvesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Snapin |
| Official Name | SNAP-associated protein [Source:MGI Symbol;Acc:MGI:1333745] |
| Ensembl ID | ENSMUSG00000001018 |
| Bio databases IDs | |
| Aliases | SNAP-associated protein |
| Synonyms | 25-kDa synaptosomal-associated, BLOC1S7, BLOS7, BORCS3, Snap25bp, SNAPAP, SNAP-associated protein, SNAPIN beta, SNAPIN β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snapin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- SNAP-25 binding domain
- PKC phosphorylation site
- Snapin/Pallidin
- coiled-coil domain
- Pka phosphorylation site
- protein binding
- hydrophobic domain
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
role in cell
- expression in
- production in
- phosphorylation in
- function
- fusion
- accumulation in
- synaptic transmission
- recruitment
- quantity
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- perinuclear region
- microvesicles
- cellular membrane
- manchette
- cytosol
- acrosome
- synaptic vesicles
- growth cone
- synaptosomes
- synapse
- cytoplasmic vesicles
- secretory granules
- perikaryon
- dendrites
- synaptic vesicle fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snapin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterograde axon cargo transport
- intracellular protein transport
- organelle transport along microtubule
- synaptic vesicle transport
- negative regulation of neuron projection development
- regulation of protein binding
- protein maturation
- synaptic vesicle exocytosis
- lysosome organization
- neuron projection development
- lysosomal lumen acidification
- endosome to lysosome transport
- neurotransmitter secretion
- lysosome localization
- neuron homeostasis
- protein complex localization
- melanosome organization
- regulation of endosome size
- terminal button organization
- synaptic vesicle fusion to presynaptic membrane
- regulation of synaptic vesicle exocytosis
- synaptic vesicle maturation
- retrograde axon cargo transport
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- BLOC-1 complex
- perinuclear region of cytoplasm
- secretory granule
- acrosomal vesicle
- synaptic vesicle
- cytosol
- Golgi membrane
- synaptic vesicle membrane
- synapse
- manchette
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNARE binding