Ybx1 Gene Summary [Mouse]
Enables chromatin binding activity; mRNA binding activity; and single-stranded DNA binding activity. Involved in epidermis development and negative regulation of cellular senescence. Acts upstream of or within several processes, including cellular response to interleukin-7; negative regulation of striated muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Located in P-body and nucleus. Part of histone pre-mRNA 3'end processing complex. Is active in synapse. Is expressed in several structures, including brain; branchial arch; facial prominence; gonad; and retina. Orthologous to human YBX1 (Y-box binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ybx1 |
| Official Name | Y box protein 1 [Source:MGI Symbol;Acc:MGI:99146] |
| Ensembl ID | ENSMUSG00000028639 |
| Bio databases IDs | |
| Aliases | Y box protein 1 |
| Synonyms | 1700102N10RIK, BP-8, Byb1, CBF-A, CSDA2, CSDB, DBPB, DBPB-LIKE, EF1A, EFI-A, MDR-NF1, MSY1, mYB-1a, NSEP-1, THYROID Y BOX, VACSSBF1, YB-1, Ybox1, Y-box Binding Protein1, Y box protein 1, YEBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ybx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- transcription regulator
- mRNA binding
- protein binding activity, bridging
- enzyme binding
- chromatin binding
- p53 binding
- protein binding
- sequence-specific DNA binding
- alanine-proline rich region
- DNA binding
- Cold shock protein domain
- RNA binding
- single-stranded DNA binding
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Ybx1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- pancreatic ductal adenocarcinoma
- metastasis
- esophageal cancer
- hypoplasia
- organismal death
- growth failure
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- phosphorylation in
- expression in
- motility
- activation
- production in
- activation in
- quantity
- apoptosis
- growth
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- GW body
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- cytosol
- spliceosomes
- nucleoplasm
- synapse
- stress granule
- perikaryon
- dendrites
- exosomes
- paraspeckle-like structures
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ybx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- epidermis development
- regulation of transcription, DNA-dependent
- mRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of striated muscle cell differentiation
- positive regulation of cell division
- positive regulation of cytoplasmic translation
- embryonic morphogenesis
- in utero embryonic development
- tRNA transport
- mRNA stabilization
- regulation of gene expression
- RNA transport
- CRD-mediated mRNA stabilization
- negative regulation of translation
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- cytoplasmic stress granule
- cytoplasmic mRNA processing body
- endoplasmic reticulum
- synapse
- extracellular region
- plasma membrane
- nucleoplasm
- nucleus
- U12-type spliceosomal complex
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- histone pre-mRNA 3'end processing complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- nucleic acid binding
- DNA binding
- protein binding
- RNA binding
- GTPase binding
- double-stranded DNA binding
- mRNA binding
- chromatin binding
- single-stranded DNA binding