Fmod Gene Summary [Mouse]
Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; heart and pericardium; jaw; limb; and skeleton. Orthologous to human FMOD (fibromodulin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmod |
| Official Name | fibromodulin [Source:MGI Symbol;Acc:MGI:1328364] |
| Ensembl ID | ENSMUSG00000041559 |
| Bio databases IDs | |
| Aliases | fibromodulin |
| Synonyms | fibromodulin, FM, SLRR2E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmod often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- uterine leiomyoma
- leiomyomatosis
- androgenic alopecia
- bruising
- squamous cell cancer of the oral cavity
- head and neck neoplasia
- oral squamous cell carcinoma
- neoplasia
- endometriosis
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- quantity
- migration
- activation in
- abnormal morphology
- invasion
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- intracellular space
- lysosomal compartment
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmod gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transforming growth factor beta receptor complex assembly
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- lysosomal lumen
- extracellular matrix
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring compression resistance