Mcm3 Gene Summary [Mouse]
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA strand elongation involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication initiation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; limb; myocardium layer; neural ectoderm; and retina. Orthologous to human MCM3 (minichromosome maintenance complex component 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm3 |
| Official Name | minichromosome maintenance complex component 3 [Source:MGI Symbol;Acc:MGI:101845] |
| Ensembl ID | ENSMUSG00000041859 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 3 |
| Synonyms | HCC5, HRLF beta subunit (P102 protein), HRLF β subunit (P102 protein), LOC367976, Mcmd, minichromosome maintenance complex component 3, Mini chromosome maintenance deficient 3, P1, P1.h, p1.m, P1-MCM3, RLFB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- MCM N-terminal domain
- ETGE motif
- MCM P-loop domain
- enzyme
- protein binding
- MCM AAA-lid domain
- DNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- MCM helicase family
Pathways
Biological processes and signaling networks where the Mcm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- hematologic cancer
- hematological neoplasia
- lymphomagenesis
- lymphoid cancer
- lymphatic neoplasia
- liver cancer
- plexiform neurofibroma
role in cell
- growth
- migration
- S phase
- replication in
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- double-strand break repair via break-induced replication
- DNA strand elongation involved in DNA replication
- regulation of DNA-dependent DNA replication initiation
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- centrosome
- perinuclear region of cytoplasm
- alpha DNA polymerase:primase complex
- CMG complex
- membrane
- nucleolus
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- single-stranded DNA binding