AABR07021402.1

Predicted to enable small GTPase binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Predicted to be located in acrosomal vesicle; cytosol; and membrane. Predicted to be part of NADPH oxidase complex. Used to study proteinuria; renal fibrosis; and status epilepticus. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07021402.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Aabr07021402.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07021402.1 gene, providing context for its role in the cell.