Rgs7 Gene Summary [Mouse]
Enables GTPase activator activity. Involved in G protein-coupled receptor signaling pathway and regulation of postsynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in dendrite terminus; nucleus; and plasma membrane. Is active in several cellular components, including dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in bone; foot mesenchyme; nervous system; pelvic girdle skeleton; and sensory organ. Orthologous to human RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs7 |
| Official Name | regulator of G protein signaling 7 [Source:MGI Symbol;Acc:MGI:1346089] |
| Ensembl ID | ENSMUSG00000026527 |
| Bio databases IDs | |
| Aliases | regulator of G protein signaling 7 |
| Synonyms | regulator of G-protein signaling 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- GGL
- Regulator of G-protein signalling DHEX domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- polycystin binding domain
- GGL domain
Pathways
Biological processes and signaling networks where the Rgs7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- fibrosis
- weight gain
- schizophrenia
- prostate cancer
- acute myeloid leukemia
- metabolic syndrome X
- hepatic steatosis
- osteonecrosis
regulates
- lipid
- reactive oxygen species
- Ca2+
- triacylglycerol
- COL1A1
- K+
- SOD
- glutathione peroxidase
- GIRK
- GTPase
role in cell
- excitability
- apoptosis
- electrophysiology
- morphology
- accumulation in
- transmembrane potential
- response
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- dendrite tip
- glutaminergic synapse
- presynaptic regions
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- presynaptic membrane
- postsynaptic membrane
- nuclear envelope
- cell tip
- dendrites
- plasma
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- response to amphetamine
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- intracellular signal transduction
- negative regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- cytoplasm
- cytosol
- macromolecular complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein beta-subunit binding
- G-protein alpha-subunit binding
- GTPase activity
- GTPase activator activity