Gnb5 Gene Summary [Mouse]
Predicted to enable several functions, including G-protein gamma-subunit binding activity; GTPase activating protein binding activity; and protein-folding chaperone binding activity. Predicted to contribute to GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway; dark adaptation; and light adaption. Located in nucleus and plasma membrane. Is active in several cellular components, including dendrite; parallel fiber to Purkinje cell synapse; and synaptic membrane. Is expressed in several structures, including brain; eye; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnb5 |
| Official Name | guanine nucleotide binding protein (G protein), beta 5 [Source:MGI Symbol;Acc:MGI:101848] |
| Ensembl ID | ENSMUSG00000032192 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein (G protein), beta 5 |
| Synonyms | flr, GB5, Gbeta5, GBS, G protein beta 5, G protein subunit beta 5, G protein subunit β 5, G protein β 5, guanine nucleotide binding protein (G protein), beta 5, guanine nucleotide binding protein (G protein), β 5, guanine nucleotide binding protein, β 5, Guan nuc b5, HG2E, IDDCA, LADCI, LDMLS1, LDMLS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnb5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- coiled-coil domain
- WD40
- GTPase activator
- enzyme
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Gnb5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Phototransduction Pathway
- Protein Kinase A Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with cardiac arrhythmia
- Huntington disease
- hereditary disorder
- COVID-19
- weight gain
- uveal melanoma
- ocular melanoma
- limited systemic sclerosis
- language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia
- diabetic nephropathy
role in cell
- apoptosis
- activation in
- expression in
- phosphorylation in
- degradation in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- nuclear fraction
- membrane fraction
- dendrite tip
- Cytoplasm
- presynaptic regions
- Nucleus
- cytosol
- presynaptic membrane
- postsynaptic membrane
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- cell tip
- perikaryon
- dendrites
- excitatory synapses
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnb5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- dopamine receptor signaling pathway
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterotrimeric G-protein complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity
- chaperone binding
- G-protein gamma-subunit binding
- receptor signaling complex scaffold activity