Gpr158 Gene Summary [Mouse]
Enables enzyme activator activity and transmembrane signaling receptor activity. Involved in several processes, including cognition; positive regulation of neurotransmitter secretion; and protein localization to plasma membrane. Located in membrane. Is active in postsynaptic density membrane. Is expressed in eye; male reproductive gland or organ; nervous system; and small intestine. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr158 |
| Official Name | G protein-coupled receptor 158 [Source:MGI Symbol;Acc:MGI:2441697] |
| Ensembl ID | ENSMUSG00000045967 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 158 |
| Synonyms | 5330427M13RIK, G protein-coupled receptor 158, LOC108348305, LOC678897, mGlyR, mKIAA1136 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr158 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-terminal conserved domain
- neurotransmitter receptor
- protein binding
- 7 transmembrane sweet-taste receptor of 3 GCPR
- enzyme activator activity
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Gpr158 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- astrocytoma
- glioma formation
- diverticular disease
- diabetic retinopathy
- oligodendroglioma
- diabetic nephropathy
- glioblastoma
- glioblastoma cancer
role in cell
- apoptosis
- proliferation
- differentiation
- organization
- inactivation in
- excitability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr158 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of synapse organization
- cognition
- positive regulation of neurotransmitter secretion
- brain development
- regulation of G-protein coupled receptor protein signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- nucleus
- postsynaptic membrane
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- enzyme activator activity