Aip Gene Summary [Mouse]
This gene encodes an Hsp90-associated protein that is localized to the cytoplasm. The encoded protein interacts with the aryl hydrocarbon receptor (AhR) and the tyrosine kinase receptor RET, inhibits AhR ubiquitination, and regulates the intracellular localization of AhR. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Aip |
| Official Name | aryl-hydrocarbon receptor-interacting protein [Source:MGI Symbol;Acc:MGI:109622] |
| Ensembl ID | ENSMUSG00000024847 |
| Bio databases IDs | |
| Aliases | aryl-hydrocarbon receptor-interacting protein |
| Synonyms | AHR interacting HSP90 co-chaperone, ARA9, aryl-hydrocarbon receptor-interacting protein, D19Bwg1412e, FKBP16, FKBP37, PITA1, SMTPHN, XAP-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunophilin homology domain
- transcription regulator
- transcription co-activator
- aryl hydrocarbon receptor binding
- peptidylprolyl isomerase
- transcription cofactor
- enzyme binding
- FKBP domain
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the Aip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- gigantism
- omphalocele
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
- sporadic acromegaly pituitary macroadenoma
- edema
- hereditary cancer-predisposing syndrome
role in cell
- expression in
- apoptosis
- activation
- production in
- activation in
- binding in
- maintenance in
- DNMDP sensitivity
- cohesion in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein maturation by protein folding
- positive regulation of transcription, DNA-dependent
- regulation of protein kinase A signaling cascade
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- aryl hydrocarbon receptor complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- GAF domain binding
- transcription coactivator activity
- aryl hydrocarbon receptor binding
- unfolded protein binding