Nme7 Gene Summary [Mouse]
Predicted to enable 3'-5' exonuclease activity and protein kinase activity. Involved in flagellated sperm motility. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; epithelial cilium movement involved in extracellular fluid movement; and intraciliary transport. Located in axonemal microtubule; centrosome; and ciliary basal body. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study hydrocephalus. Orthologous to human NME7 (NME/NM23 family member 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Nme7 |
| Official Name | NME/NM23 family member 7 [Source:MGI Symbol;Acc:MGI:2449121] |
| Ensembl ID | ENSMUSG00000026575 |
| Bio databases IDs | |
| Aliases | NME/NM23 family member 7 |
| Synonyms | CFAP67, D530024H21Rik, MN23H7, NDK 7, nm23-H7, Nm23-M7, Nm23-r7, NME/NM23 family member 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nme7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 3'-5' exonuclease
- nucleoside diphosphate kinase
- protein kinase
- Nucleoside diphosphate kinase family
- DM10 domain
- NDPk
- protein binding
- Domains in hypothetical proteins in Drosophila, C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- COVID-19
- adenomyosis
- venous thromboembolism
- coronary artery disease
- phlebitis
- thrombophlebitis
- lipoma
- lipomatosis
- thrombophilia
regulated by
- TREM1
- bisphenol A
- nonylphenol
- Salmonella enterica serotype abortus equi lipopolysaccharide
- genistein
role in cell
- phosphorylation in
- growth
- motility
- nucleation
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- basal bodies
- centrosome
- axonemes
- cytosol
- nucleoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nme7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UTP biosynthetic process
- CTP biosynthetic process
- GTP biosynthetic process
- regulation of microtubule nucleation
Cellular Component
Where in the cell the gene product is active
- nucleus
- axonemal microtubule
- centrosome
- motile cilium
- cytoplasm
- spindle
- cytosol
- gamma-tubulin large complex
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- ATP binding
- protein binding
- protein kinase activity
- nucleoside diphosphate kinase activity