Trem1 Gene Summary [Mouse]
Predicted to enable receptor decoy activity; scaffold protein binding activity; and transmembrane signaling receptor activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trem1 |
| Official Name | triggering receptor expressed on myeloid cells 1 [Source:MGI Symbol;Acc:MGI:1930005] |
| Ensembl ID | ENSMUSG00000042265 |
| Bio databases IDs | |
| Aliases | triggering receptor expressed on myeloid cells 1 |
| Synonyms | AC241601.2, CD354, triggering receptor expressed on myeloid cells 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- loop domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Trem1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- periodontitis
- experimental keratitis
- pneumonia
- experimental colitis
- Crohn disease
- osteoarthritis
- diabetic nephropathy
- acute kidney injury
- septic shock
role in cell
- proliferation
- expression in
- phosphorylation in
- production in
- apoptosis
- activation in
- degranulation
- differentiation
- adhesion
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- azurophil granules
- specific granules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine production involved in immune response
- innate immune response
- humoral immune response
- adaptive immune response
- neutrophil chemotaxis
- chemokine production
- neutrophil mediated killing of gram-negative bacterium
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- transmembrane signaling receptor activity
- signaling receptor activity