Astn1 Gene Summary [Mouse]
Acts upstream of or within locomotory behavior; neuron cell-cell adhesion; and neuron migration. Located in endosome and external side of plasma membrane. Is expressed in several structures, including central nervous system; future brain; and retina. Orthologous to human ASTN1 (astrotactin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Astn1 |
| Official Name | astrotactin 1 [Source:MGI Symbol;Acc:MGI:1098567] |
| Ensembl ID | ENSMUSG00000026587 |
| Bio databases IDs | |
| Aliases | astrotactin 1 |
| Synonyms | ASTN, astrotactin 1, GC14, KIAA0289, LOC304900, mKIAA0289 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Astn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ASTN1/2 EGF-like and Fn(III) domains
- membrane-attack complex / perforin
- protein binding
- Astrotactin 1/2 N-terminal
- Coagulation Factor Xa inhibitory site
- Annexin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- clathrin-coated structures
- cellular membrane
- endosomes
- plasma membrane extracellular face
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Astn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- locomotory behavior
- neuron cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- external side of plasma membrane
- clathrin-coated vesicle
- perikaryon