Brsk2 Gene Summary [Mouse]
Enables protein kinase binding activity and tau-protein kinase activity. Involved in several processes, including microtubule cytoskeleton organization involved in establishment of planar polarity; regulation of axonogenesis; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within central nervous system neuron differentiation; neuron projection morphogenesis; and peptidyl-serine phosphorylation. Predicted to be located in distal axon and endoplasmic reticulum. Predicted to be active in centrosome. Is expressed in several structures, including central nervous system and retina. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brsk2 |
| Official Name | BR serine/threonine kinase 2 [Source:MGI Symbol;Acc:MGI:1923020] |
| Ensembl ID | ENSMUSG00000053046 |
| Bio databases IDs | |
| Aliases | BR serine/threonine kinase 2 |
| Synonyms | 4833424K13Rik, BR serine/threonine kinase 2, C11orf7, LOC103691267, LOC685286, PEN11B, SAD1, SAD-A, STK29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brsk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Tau-protein kinase
- ATPase binding
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- schizophrenia
- heroin dependence
- hereditary disorder
- bradykinesia
- neurodevelopmental disorder
- familial hemolytic anemia
- complex neurodevelopmental disorder
role in cell
- phosphorylation in
- outgrowth
- abnormal morphology
- differentiation
- binding in
- DNA damage response
- G2/M phase transition
- clustering
- organization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brsk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- neuron differentiation
- microtubule cytoskeleton organization involved in establishment of planar polarity
- protein phosphorylation
- exocytosis
- cell division
- G2/M transition of mitotic cell cycle
- regulation of synaptic vesicle clustering
- regulation of axonogenesis
- axonogenesis
- regulation of ATPase activity
- establishment of cell polarity
- regulation of neuron projection development
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- tau-protein kinase activity
- ATP binding
- protein kinase binding
- protein binding
- ATPase regulator activity
- tau protein binding
- protein serine/threonine kinase activity
- ATPase binding