Med27 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of core mediator complex; mediator complex; and ubiquitin ligase complex. Is expressed in genitourinary system and tibialis anterior. Orthologous to human MED27 (mediator complex subunit 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med27 |
| Official Name | mediator complex subunit 27 [Source:MGI Symbol;Acc:MGI:1916225] |
| Ensembl ID | ENSMUSG00000026799 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 27 |
| Synonyms | 1500015J03Rik, 2310042P07Rik, CRAP34, CRSP34, CRSP8, D2Ertd434e, LOC100134189, MED3, mediator complex subunit 27, NEDSCAC, RGD1564993, TRAP37 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- protein binding
- Mediator complex subunit 27
Pathways
Biological processes and signaling networks where the Med27 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- non-insulin-dependent diabetes mellitus
- neurodevelopmental disorder with spasticity, cataracts, and cerebellar hypoplasia
- metabolic syndrome X
- insomnia
- pervasive developmental disorder
- productive infection by HIV-1
regulated by
- MYC
- cocaine
- camptothecin
regulates
- RNA polymerase II
- TBP
- DNA promoter
- DNA endogenous promoter
role in cell
- transactivation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- somatic stem cell maintenance
- transcription initiation from RNA polymerase II promoter
- protein ubiquitination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- ubiquitin ligase complex
- mediator complex
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity